Sleep Problems – New Investigation Findings on Restless Leg Syndrome Medicine Trials


Writing about sleep medicines has not been a massive part of my focus on how to increase sleep problems.  But these current findings from the American Association of Neurology provide achievable hope to these plagued with a sleep disorder that is neurological in origin, and deserve mention.  All research must be viewed with caution as an initial try to match a modest piece of information into a bigger physique of findings.  Only when it has been replicated by other analysis, or studied on a longer term basis, can its location in the physique of science be understood.

Restless Leg Syndrome (RLS) is not only a sleep disorder, but also a daytime issue which worsens at night, and, far more importantly, interferes with the architecture of sleep by robbing the sufferer of the deeper stages of sleep.  This means that the particular person with RLS seldom gets a great night’s sleep and experiences all of the daytime maladies of lacking good restorative sleep. 

The main symptoms of RLS are creepy, crawly, tingling , burning or numbing sensations in the legs which underlie an urge to move the legs or to get up and walk to relieve the symptoms.  Walking or other activity does relieve the dilemma temporarily, but sensations return when the particular person is at rest.  When symptoms get worse at night, they interfere with the deeper stages of sleep, typically awakening the individual or their bed partner with kicking movements.  Diagnosis of this disorder is ideal created by a neurologist or through an overnight sleep study, exactly where leg movements are really recorded graphically, like an EEG or EKG.

Dr. Diego Garcia-Borreguerro, Director of the Sleep Study Institute in Madrid, Spain reported in April, 2009 on a study his clinic conducted, jointly funded by Pfizer Pharmaceuticals. In his study, the medicine Pregabalin (aka Lyrica) was prescribed on a brief term basis (12 weeks) to patients with RLS.  Findings had been substantial for 66 % of the study participants, for whom Pregabalin relieved all of their RLS symptoms while  these with remaining symptoms reported 66% improvement.

This distinct medicine had already received FDA approval for and is at the moment being used to treat epilepsy, fibromyalgia, nerve discomfort and generalized anxiousness.  Other medicines authorized for treatment of RLS have shown great guarantee for short-term relief of symptoms, but frequently contain the rebound impact of obtaining symptoms return in even stronger kind more than the extended term.  They all have in frequent that they treat by means of dopamine pathways, which Pregabalin does not, and, for the most element, do not increase the deeper stages of sleep. 

Maybe the most optimistic aspect of this study is the obtaining of the restoration of Stages three and 4 sleep over the course of this quick term study.  If this discovering holds true for longer term use in other studies, it will be a remarkable aid to poor sleep worth examining.