Removing just one enzyme permanently prevents obesity in mice
In the course of research conducted by a team of scientists at the University of Copenhagen, it was possible to find out that the genetic removal of only one enzyme in mice deprives them of the possibility of gaining weight in the future even when eating high-calorie foods.
Scientists have called this enzyme NAMPT. As in animals and humans, he is responsible for the processes associated with obesity. It was found that being in adipose tissue, it strengthens metabolic processes in many other tissues, which contributes to the accumulation of fat in the body.
To understand the mechanism of his work, the researchers withdrew mice, deprived of the enzyme NAMPT in their fat tissue. When these experimental mice received high-fat foods, they did not get fat. Simultaneously with them the mice with NAMPT safely gained weight.
This study undoubtedly deserves the closest attention, but, unfortunately, it is too early to speak about the application of its results in medicine. As scientists have established, NAMPT can accumulate in various organs and tissues, resulting in the risk of dangerous side effects. Now the university team is studying the possibility of using an enzyme for the treatment of cancer .